Professor Yoshizawa

# indicates co-first author, and * indicates corresponding author.

  1. Yamagata K*, Mizumoto T, Yoshizawa T: The Emerging Role of SIRT7 in Glucose and Lipid Metabolism. Cells 13(1): 48, 2023.
  2. Tsuyama T, Sato Y, Yoshizawa T, Matsuoka T, Yamagata K*: Hypoxia causes pancreatic β-cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE40. EMBO Rep 24: e56227, 2023.
  3. Yoshizawa T*, Sato Y, Sobuz SU, Mizumoto T, Tsuyama T, Karim MF, Miyata K, Tasaki M, Yamazaki M, Kariba Y, Araki N, Araki E, Kajimura S, Oike Y, Braun T, Bober E, Auwerx J, Yamagata K*: SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice. Nat Commun 13: 7439, 2022.
  4. Mizumoto T, Yoshizawa T, Sato Y, Ito T, Tsuyama T, Satoh A, Araki S, Tsujita K, Tamura M, Oike Y, Yamagata K*: SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice. Cells 11(22): 3609, 2022.
  5. Sakaguchi M*, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki E: Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nat Commun 2022, 13: 6092.
  6. Mizutani H, Sato Y*, Yamazaki M, Yoshizawa T, Ando Y, Ueda M, Yamagata K*: SIRT7 deficiency protects against Aβ42-induced apoptosis through the regulation of NOX4-derived reactive oxygen species production in SH-SY5Y cells. Int J Mol Sci 23(16): 9027, 2022.
  7. Yoshikawa Y*, Tamura A, Tsuda S, Domae E, Zhang S, Yui N, Ikeo T, Yoshizawa T: Calcium phosphate-adsorbable and acid-degradable carboxylated polyrotaxane consisting of β-cyclodextrins suppresses osteoclast resorptive activity. Dent Mater J 41(4): 624-632, 2022.
  8. Akter F, Tsuyama T, Yoshizawa T*, Sobuz SU, Yamagata K: SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2. J Diabetes Investig 12(10): 1765-1774, 2021.
  9. Kimura Y, Izumiya Y*, Araki S, Yamamura S, Hanatani S, Onoue Y, Ishida T, Arima Y, Nakamura T, Yamamoto E, Senokuchi T, Yoshizawa T, Sata M, Kim-Mitsuyama S, Nakagata N, Bober E, Braun T, Kaikita K, Yamagata K, Tsujita K: Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation. Circ J 85(12): 2232-2240, 2021.
  10. Kariba Y, Yoshizawa T*, Sato Y, Tsuyama T, Araki E, Yamagata K: Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes. Biochem Biophys Res Commun 530(3): 500-507, 2020.
  11. Sato Y, Rahman MM, Haneda M, Tsuyama T, Mizumoto T, Yoshizawa T, Kitamura T, Gonzalez FJ, Yamamura KI, Yamagata K*: HNF1α controls glucagon secretion in pancreatic β-cells through modulation of SGLT1. Biochim Biophys Acta Mol Basis Dis 1866(11): 165898-165898, 2020.
  12. Yamamura S, Izumiya Y*, Araki S, Nakamura T, Kimura Y, Hanatani S, Yamada T, Ishida T, Yamamoto M, Onoue Y, Arima Y, Yamamoto E, Sunagawa Y, Yoshizawa T, Nakagata N, Bober E, Braun T, Sakamoto K, Kaikita K, Morimoto T, Yamagata K, Tsujita K: Cardiomyocyte Sirt7 ameliorates stress-induced cardiac hypertrophy by interacting with and deacetylating GATA4. Hypertension 75(1): 98–108, 2020.
  13. Yoshikawa Y*, Yoshizawa T, Domae E, Hirai Y, Kamada A, Okazaki T, Ikeo T: Knockdown of sphingomyelin synthase 2 inhibits osteoclastogenesis by decreasing RANKL expression in mouse primary osteoblast. Biomed Res (Tokyo) 40(5): 189-196, 2019.
  14. Sobuz SU, Sato Y, Yoshizawa T, Karim F, Ono K, Sawa T, Miyamoto Y, Oka M, Yamagata K*: SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran. Biochim Biophys Acta Mol Cell Res 1866(9): 1355-1367, 2019.
  15. Fukuda M#, Yoshizawa T#*, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K: SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix. Nat Commun 9: 2833, 2018.
  16. Miyasato Y, Yoshizawa T, Sato Y, Nakagawa T, Miyasato Y, Kakizoe Y, Kuwabara T, Adachi M, Ianni A, Braun T, Komohara Y, Mukoyama M, Yamagata K*: Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response. Sci Rep 8: 5927, 2018.
  17. Korogi W, Yoshizawa T*, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K: SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development. Biochem Biophys Res Commun 496: 891-897, 2018.
  18. Yamagata K*, Yoshizawa T: Transcriptional Regulation of Metabolism by SIRT1 and SIRT7. Int Rev Cell Mol Biol 335: 143-166, 2017.
  19. Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y*: Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.  J Biol Chem 293: 1596-1609, 2017.
  20. Islam MS, Wei FY, Ohta K, Shigematsu N, Fukuda T, Tomizawa K, Yoshizawa T*, Yamagata K: Sirtuin 7 is involved in the consolidation of fear memory in mice. Biochem Biophys Res Commun 495: 261-266, 2017.
  21. Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y*: Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor. Osteoarthritis Cartilage 26: 108-117, 2017.
  22. Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K*: Sirtuin7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4. Biochem Biophys Res Commun 490: 423-428, 2017.
  23. Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K*: Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase. J Biol Chem 292: 8716-8728, 2017.
  24. Yamagata K*, Karim MF, Sato Y, Yoshizawa T: Role of SIRT7 in hepatic lipid metabolism. Diabetol Int 6(3): 193-196, 2015.
  25. Araki S, Izumiya Y*, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H: Sirt7 Contributes to Myocardial Tissue Repair by Maintaining TGF-β Signaling Pathway. Circulation 132: 1081-1093, 2015.
  26. Yoshikawa Y*, Yoshizawa T, Domae E, Hieda Y, Takeyama A, Hirota S, Kawamoto A, Goda S, Tamura I, Kamada A, Komasa Y, Morita S, Yamagata K, Ikeo T: RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor κB ligand expression induced by BMP-2 in primary osteoblasts. Arch Oral Biol 60: 1319–1326, 2015.
  27. Hayashi H, Sato Y, Li Z, Yamamura K, Yoshizawa T, Yamagata K*: Roles of hepatic glucokinase in intertissue metabolic communication: Examination of novel liver-specific glucokinase knockout mice. Biochem Biophys Res Commun 460: 727-732, 2015.
  28. Sato Y, Inoue M, Yoshizawa T, Yamagata K*: Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes. PLoS One 9(12): e114868, 2014.
  29. Yoshizawa T, Karim MF, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Takeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K*: SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway. Cell Metab 19(4): 712-721, 2014.
  30. Ohki T, Utsu Y, Morita S, Karim MF, Sato Y, Yoshizawa T, Yamamura K, Yamada K, Kasayama S, Yamagata K*: Low serum level of high-sensitivity C-reactive protein in a Japanese subject with MODY3. J Diabetes Investig 5(5): 513–516, 2014.
  31. Karim MF, Yoshizawa T, Sato Y, Sawa T, Tomizawa K, Akaike T, Yamagata K*: Inhibition of H3K18 deacetylation of Sirt7 by Myb-binding protein 1a (Mybbp1a). Biochem Biophys Res Commun 441(1): 157-163, 2013.
  32. Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato, T, Kawano H, Aihara K, Nakamichi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y*: Vitamin D receptor in osteoblasts is a negative regulator of bone mass control.   Endocrinology 154(3): 1008-1020, 2013.
  33. Ohki T, Sato Y, Yoshizawa T, Yamamura K, Yamada K, Yamagata K*: Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells. Biochem Biophys Res Commun 425(3): 619-624, 2012.
  34. Sato Y, Hatta M, Karim MF, Sawa T, Wei FY, Sato S, Magnuson MA, Gonzalez FJ, Tomizawa K, Akaike T, Yoshizawa T, Yamagata K*: Anks4b, a novel target of HNF4α interacts with GRP78 and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. J Biol Chem 287(27): 23236-23245, 2012.
  35. Yamagata K*, Senokuchi T, Lu M, Takemoto M, Karim MF, Go C, Sato Y, Hatta M, Yoshizawa T, Araki E, Miyazaki J, Song WJ: Voltage-gated K(+) channel KCNQ1 regulates insulin secretion in MIN6 β-cell line. Biochem Biophys Res Commun 407(3): 620-625, 2011.
  36. Ferron M#, Wei J#, Yoshizawa T#, Henriksen K, Fattore AD, DePinho RA, Bollerslev J, Teti A, Ducy P, Karsenty G*: Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142(2): 296-308, 2010.
  37. Ferron M, Wei J, Yoshizawa T, Ducy P, Karsenty G*: An elisa-based method to quantify osteocalcin carboxylation in mice. Biochem Biophys Res Commun 397(4): 691-696, 2010.
  38. Ishibashi O*, Ikegame M, Takizawa F, Yoshizawa T, Moksed MA, Iizawa F, Mera H, Matsuda A, Kawashima H*: Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation. J Cell Physiol 222(2): 465-473, 2010.
  39. Yoshizawa T, Hinoi E, Jung DY, Kajimura D, Ferron M, Seo J, Graff JM, Kim JK, Karsenty G*: The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts. J Clin Invest 119(9): 2807-2817, 2009.
  40. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Kajimura D, Myers MG Jr, Chua SC Jr, Wang Q, Kim JK, Kaestner KH, Karsenty G*: An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann N Y Acad Sci 1173(S1): E20-30, 2009.
  41. Mera H, Kawashima H, Yoshizawa T, Ishibashi O, Ali MM, Hayami T, Kitahara H, Yamagiwa H, Kondo N, Ogose A, Endo N, Kawashima H*: Chondromodulin-1 directly suppresses growth of human cancer cells. BMC Cancer 9: 166, 2009.
  42. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers MG Jr, Chua SC Jr, Kim JK, Kaestner KH, Karsenty G*: The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 183(7): 1235-1242, 2008.
  43. Ali MM, Yoshizawa T, Ishibashi O, Matsuda A, Ikegame M, Shimomura J, Mera H, Nakashima K, Kawashima H*: PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts. J Cell Sci 120: 2565-2573, 2007.
  44. Iguchi S, Nishi S, Ikegame M, Hoshi K, Yoshizawa T, Kawashima H, Arakawa M, Ozawa H, Gejyo F*: Expression of osteopontin in cisplatin-induced tubular injury. Nephron Exp Nephrol 97: e96-105, 2004.
  45. Gu W, Ogose A, Kawashima H, Ito M, Ito T, Matsuba A, Kitahara H, Hotta T, Tokunaga K, Hatano H, Morita T, Urakawa S, Yoshizawa T, Kawashima H, Kuwano R, Endo N*: High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing's sarcoma, and benign neurogenic tumors among musculoskeletal tumors.  Clin Cancer Res 10: 3831-3838, 2004.
  46. Yoshizawa T, Takizawa F, Iizawa F, Ishibashi O, Kawashima H, Matsuda A, Endo N, Kawashima H*: Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblast. Mol Cell Biol 24: 3460-3472, 2004.
  47. Sato T, Matsumoto T, Kawano H, Watanabe T, Uematsu Y, Sekine K, Fukuda T, Aihara K, Krust A, Yamada T, Nakamichi Y, Yamamoto Y, Nakamura T, Yoshimura K, Yoshizawa T, Metzger D, Chambon P, Kato S*: Brain masculinization requires androgen receptor function. Proc Natl Acad Sci USA 101: 1673-1678, 2004.
  48. Endo I, Inoue D, Mitsui T, Umaki Y, Akaike M, Yoshizawa T, Kato S, Matsumoto T*: Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144: 5138-5144, 2003.
  49. Kawano H, Sato T, Yamada T, Matsumoto T, Sekine K, Watanabe T, Nakamura T, Fukuda T, Yoshimura K, Yoshizawa T, Aihara KI, Yamamoto Y, Nakamichi Y, Metzger D, Chambon P, Nakamura K, Kawaguchi H, Kato S*: Suppressive function of androgen receptor in bone resorption. Proc Natl Acad Sci USA 100: 9416-9421, 2003.
  50. Shimomura J, Ishibashi O, Ikegame M, Yoshizawa T, Ejiri S, Noda T, Kawashima H*: Tensile stress induces alpha-adaptin C production in mouse calvariae in an organ culture: Possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation. J Cell Physiol 195: 488-496, 2003.
  51. Kawashima H, Ogose A, Yoshizawa T, Kuwano R, Hotta Y, Hotta T, Hatano H, Kawashima H, Endo N*: Expression of the coxsackievirus and adenovirus receptor in musculoskeletal tumors and mesenchymal tissues: efficacy of adenoviral gene therapy for osteosarcoma. Cancer Sci 94: 70-75, 2003.
  52. Saito Y#, Yoshizawa T#, Takizawa F, Ikegame M, Ishibashi O, Okuda K, Hara K, Ishibashi K, Obinata M, Kawashima H*: A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. J Cell Sci 115: 4191-4200, 2002.
  53. Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, Bikle DD*: Lack of the Vitamin D Receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol 118: 11-16, 2002.
  54. Kato S*, Yoshizawa T, Kitanaka S, Murayama A, Takeyama K: Molecular genetics of vitamin D-dependent hereditary rickets. Horm Res 57: 73-78, 2002.
  55. Yagishita N#, Yamamoto Y#, Yoshizawa T#, Sekine K, Uematsu Y, Murayama H, Nagai Y, Krezel W, Chambon P, Matsumoto T, Kato S*: Aberant growth plate development in VDR/RXRγ double null mutant mice.      Endocrinology 142: 5332-5341, 2001.
  56. Masuyama R, Nakaya Y, Tanaka S, Tsurukami H, Nakamura T, Watanabe S, Yoshizawa T, Kato S, Suzuki K*: Dietary phosphorus restriction reverses the impaired bone mineralization in vitamin D receptor knockout mice. Endocrinology 142: 494-497, 2001.
  57. Ikegame M, Ishibashi O, Yoshizawa T, Shimomura J, Komori T, Ozawa H, Kawashima H*: Tensile stress induces Bone Morphogenetic Protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ culture. J Bone Miner Res 16: 24-32, 2001.
  58. Kato S*, Takeyama K, Kitanaka S, Murayama A, Sekine K, Yoshizawa T: In vivo function of VDR in gene expression-VDR knockout mice. J Steroid Biochem Mol Biol (Review) 69: 247-251, 1999.
  59. Sekine K, Ohuchi H, Fujiwara M, Yamasaki M, Yoshizawa T, Sato T, Yagishita N, Matsui D, Koga Y, Itoh N, Kato S*: FGF10 is essential for the limb and lung formation. Nat Genet 21: 138-141, 1999.
  60. Takeda S, Yoshizawa T, Nagai Y, Yamato H, Fukumoto S, Sekine K, Kato S, Matsumoto T, Fujita T*: Stimulation of osteoclast formation by 1,25-dihydroxy-vitamin D requires its binding to vitamin D receptor (VDR) in osteoblastic cells: Studies using VDR knockout mice. Endocrinology 140: 1005-1008, 1999.
  61. Kato S*, Matsumoto T, Sekine K, Yoshizawa T: Molecular genetics of vitamin D receptor acting in bone. J Bone Miner Metab (Review) 16: 65-71, 1998.
  62. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchiyama Y, Masushige S, Fukamizu A, Matsumoto T, Kato S*: Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet 16: 391-396, 1997.
  63. Yamamoto Y, Yoshizawa T, Kamio S, Aoki O, Kawamata Y, Masushige S, Kato S*: Interactions of transthyretin (TTR) and retinol-binding protein (RBP) in the uptake of retino by primary rat hepatocytes. Exp Cell Res 234: 373-378, 1997.
  64. Ebihara K, Masuhiro Y, Kitamoto T, Suzawa M, Uematsu Y, Yoshizawa T, Ono T, Harada H, Matsuda K, Hasegawa T, Masushige S, Kato S*: Intron retention generates a novel isoform of the murine vitamin D receptor that acts in a dominant negative way on the vitamin D signaling pathway. Mol Cell Biol 16: 3393-3400, 1996.
  65. Yamamoto Y, Yoshizawa T, Mano H, Masushige S, Kato S*: Expression of functional rat retinol-binding protein in Escherichia coli. J Nutr Sci Vitaminol 42: 257-266, 1996

Dr. Yamada

  1. Efficient Production of Chondrocyte Particles from Human iPSC-Derived Chondroprogenitors Using a Plate-Based Cell Self-Aggregation Technique. Shojiro Hanaki, Daisuke Yamada, Tomoka Takao, Ryosuke Iwai, Takeshi Takarada. International journal of molecular sciences 25(22) 2024
  2. PRRX1 upregulates PD-L1 in human mesenchymal stem cells. Taro Osawa, Daisuke Yamada, Tomoko Takao, Lu Ming, Takeshi Takarada. In vitro cellular & developmental biology. Animal 2024
  3. PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours. Shota Takihira, Daisuke Yamada, Tatsunori Osone, Tomoka Takao, Masakiyo Sakaguchi, Michiyuki Hakozaki, Takuto Itano, Eiji Nakata, Tomohiro Fujiwara, Toshiyuki Kunisada, Toshifumi Ozaki, Takeshi Takarada. British journal of cancer 2024
  4. Antitumor activity of α-pinene in T-cell tumors. Masaya Abe, Noboru Asada, Maiko Kimura, Chie Fukui, Daisuke Yamada, Ziyi Wang, Masayuki Miyake, Takeshi Takarada, Mitsuaki Ono, Michinori Aoe, Wataru Kitamura, Masayuki Matsuda, Takashi Moriyama, Akifumi Matsumura, Yoshinobu Maeda. Cancer science 2024
  5. Alpha-Pinene As a Novel Therapeutic Agent for T-Cell Tumors Masaya Abe, Noboru Asada, Maiko Kimura, Chie Fukui, Daisuke Yamada, Ziyi Wang, Masayuki Miyake, Takeshi Takarada, Mitsuaki Ono, Michinori Aoe, Wataru Kitamura, Masayuki Matsuda, Takashi Moriyama, Akifumi Matsumura, Yoshinobu Maeda. Blood 142(Supplement 1) 1441-1441 2023
  6. Development of cartilage tissue using a stirred bioreactor and human iPSC-derived limb bud mesenchymal cells. Yuki Fujisawa, Tomoka Takao, Daisuke Yamada, Takeshi Takarada. Biochemical and biophysical research communications 687 149146-149146 2023
  7. Fabrication of shape-designable cartilage from human induced pluripotent stem cell-derived chondroprogenitors using a cell self-aggregation technique. Tomoyuki Ota, Tomoka Takao, Ryosuke Iwai, Takeshi Moriwaki, Yohei Kitaguchi, Yuki Fujisawa, Daisuke Yamada, Yoshihiro Kimata, Takeshi Takarada. Biomedical materials (Bristol, England) 2023
  8. A novel chondrocyte sheet fabrication using human-induced pluripotent stem cell-derived expandable limb-bud mesenchymal cells. Tomoka Takao, Masato Sato, Yuki Fujisawa, Eriko Toyoda, Daisuke Yamada, Yukio Hitsumoto, Eiji Nakata, Toshifumi Ozaki, Takeshi Takarada. Stem cell research & therapy 14(1) 34-34 2023
  9. A protocol to induce expandable limb-bud mesenchymal cells from human pluripotent stem cells. Tomoka Takao, Daisuke Yamada, Takeshi Takarada. STAR protocols 3(4) 101786-101786 2022
  10. Establishment of a human pluripotent stem cell-derived MKX-tdTomato reporter system. Yuki Fujisawa, Lu Ming, Daisuke Yamada, Tomoka Takao, Takeshi Takarada. Stem cell research & therapy 13(1) 515-515 2022
  11. Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling. Haoze Yuan, Mika Ikegame, Yoko Fukuhara, Fumiko Takemoto, Yaqiong Yu, Jumpei Teramachi, Yao Weng, Jiajie Guo, Daisuke Yamada, Takeshi Takarada, Ying Li, Hirohiko Okamura, Bin Zhang. Calcified tissue international 111(3) 331-344 2022
  12. Identification of Surface Antigens That Define Human Pluripotent Stem Cell-Derived PRRX1+Limb-Bud-like Mesenchymal Cells. Daisuke Yamada, Tomoka Takao, Masahiro Nakamura, Toki Kitano, Eiji Nakata, Takeshi Takarada. International journal of molecular sciences 23(5) 2022
  13. Mouse Model for Optogenetic Genome Engineering. Tomoka Takao, Daisuke Yamada, Takeshi Takarada. Acta medica Okayama 76(1) 1-5 2022
  14. Oncogenic potential of human pluripotent stem cell-derived lung organoids with HER2 overexpression. Akihiro Miura, Daisuke Yamada, Masahiro Nakamura, Shuta Tomida, Dai Shimizu, Yan Jiang, Tomoka Takao, Hiromasa Yamamoto, Ken Suzawa, Kazuhiko Shien, Masaomi Yamane, Masakiyo Sakaguchi, Shinichi Toyooka, Takeshi Takarada. International journal of cancer 149(8) 1593-1604 2021
  15. O-GlcNAcylation drives calcium signaling toward osteoblast differentiation: A bioinformatics-oriented study. Yao Weng, Ziyi Wang, Yoko Fukuhara, Airi Tanai, Mika Ikegame, Daisuke Yamada, Takeshi Takarada, Takashi Izawa, Satoru Hayano, Kaya Yoshida, Hiroshi Kamioka, Hirohiko Okamura. BioFactors (Oxford, England) 47(6) 992-1015 2021
  16. Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells. Daisuke Yamada, Masahiro Nakamura, Tomoka Takao, Shota Takihira, Aki Yoshida, Shunsuke Kawai, Akihiro Miura, Lu Ming, Hiroyuki Yoshitomi, Mai Gozu, Kumi Okamoto, Hironori Hojo, Naoyuki Kusaka, Ryosuke Iwai, Eiji Nakata, Toshifumi Ozaki, Junya Toguchida, Takeshi Takarada. Nature biomedical engineering 5(8) 926-940 2021
  17. PRRX1 promotes malignant properties in human osteosarcoma. Ryoji Joko, Daisuke Yamada, Masahiro Nakamura, Aki Yoshida, Shota Takihira, Tomoka Takao, Ming Lu, Kohei Sato, Tatsuo Ito, Toshiyuki Kunisada, Eiji Nakata, Toshifumi Ozaki, Takeshi Takarada. Translational oncology 14(1) 100960-100960 2021
  18. Establishment of a tTA-dependent photoactivatable Cre recombinase knock-in mouse model for optogenetic genome engineering. Tomoka Takao, Yuichi Hiraoka, Kenji Kawabe, Daisuke Yamada, Lu Ming, Kohichi Tanaka, Moritoshi Sato, Takeshi Takarada. Biochemical and biophysical research communications 526(1) 213-217 2020
  19. Postnatal Runx2 deletion leads to low bone mass and adipocyte accumulation in mice bone tissues. Tosa I, Yamada D, Yasumatsu M, Hinoi E, Ono M, Oohashi T, Kuboki T, Takarada T. Biochemical and biophysical research communications 516(4) 1229-1233 2019
  20. Runx2 function in cells of neural crest origin during intramembranous ossification. Shirai Y, Kawabe K, Tosa I, Tsukamoto S, Yamada D, Takarada T. Biochemical and biophysical research communications 509(4) 1028-1033 2019
  21. Design, synthesis, and biological evaluation of radioiodinated benzo[d]imidazole-quinoline derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging. Effendi N, Mishiro K, Takarada T, Yamada D, Nishii R, Shiba K, Kinuya S, Odani A, Ogawa K. Bioorganic & medicinal chemistry 27(2) 383-393 2019
  22. Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system. Yamada D, Kawabe K, Tosa I, Tsukamoto S, Nakazato R, Kou M, Fujikawa K, Nakamura S, Ono M, Oohashi T, Kaneko M, Go S, Hinoi E, Yoneda Y, Takarada T. Communications biology 2 346-346 2019
  23. RUNX2 Promotes Malignant Progression in Glioma. Yamada D, Fujikawa K, Kawabe K, Furuta T, Nakada M, Takarada T. Neurochemical research 43(11) 2047-2054 2018
  24. Radiobrominated benzimidazole-quinoline derivatives as Platelet-derived growth factor receptor beta (PDGFR beta) imaging probes. Effendi Nurmaya, Mishiro Kenji, Takarada Takeshi, Makino Akira, Yamada Daisuke, Kitamura Yoji, Shiba Kazuhiro, Kiyono Yasushi, Odani Akira, Ogawa Kazuma. SCIENTIFIC REPORTS 8(1) 10369-10369 2018
  25. Disruption of Bmal1 Impairs Blood-Brain Barrier Integrity via Pericyte Dysfunction. Ryota Nakazato, Kenji Kawabe, Daisuke Yamada, Shinsuke Ikeno, Michihiro Mieda, Shigeki Shimba, Eiichi Hinoi, Yukio Yoneda, Takeshi Takarada. JOURNAL OF NEUROSCIENCE 37(42) 10052-10062 2017
  26. Synthesis and evaluation of radioiodinated 1-{2-[5-(2-methoxyethoxy)-1H-benzo[d]imidazol-1-yl]quinolin-8-yl}piperidin-4-amine derivatives for platelet-derived growth factor receptor beta (PDGFR beta) imaging. Nurmaya Effendi, Kazuma Ogawa, Kenji Mishiro, Takeshi Takarada, Daisuke Yamada, Yoji Kitamura, Kazuhiro Shiba, Takehiko Maeda, Akira Odani. BIOORGANIC & MEDICINAL CHEMISTRY 25(20) 5576-5585 2017
  27. Bone Resorption Is Regulated by Circadian Clock in Osteoblasts. Takeshi Takarada, Cheng Xu, Hiroki Ochi, Ryota Nakazato, Daisuke Yamada, Saki Nakamura, Ayumi Kodama, Shigeki Shimba, Michihiro Mieda, Kazuya Fukasawa, Kakeru Ozaki, Takashi Iezaki, Koichi Fujikawa, Yukio Yoneda, Rika Numano, Akiko Hida, Hajime Tei, Shu Takeda, Eiichi Hinoi. JOURNAL OF BONE AND MINERAL RESEARCH 32(4) 872-881 2017
  28. The Intrinsic Microglial Clock System Regulates Interleukin-6 Expression. Ryota Nakazato, Shogo Hotta, Daisuke Yamada, Miki Kou, Saki Nakamura, Yoshifumi Takahata, Hajime Tei, Rika Numano, Akiko Hida, Shigeki Shimba, Michihiro Mieda, Eiichi Hinoi, Yukio Yoneda, Takeshi Takarada. GLIA 65(1) 198-208 2017
  29. Plexin A1 signaling confers malignant phenotypes in lung cancer cells. Daisuke Yamada, Satoshi Watanabe, Kohichi Kawahara, Takehiko Maeda. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 480(1) 75-80 2016
  30. Autocrine Semaphorin3A signaling is essential for the maintenance of stem-like cells in lung cancer. Daisuke Yamada, Kensuke Takahashi, Kohichi Kawahara, Takehiko Maeda. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 480(3) 375-379 2016
  31. The Novel Monoclonal Antibody 9F5 Reveals Expression of a Fragment of GPNMB/Osteoactivin Processed by Furin-like Protease(s) in a Subpopulation of Microglia in Neonatal Rat Brain. Kohichi Kawahara, Hiroshi Hirata, Kengo Ohbuchi, Kentaro Nishi, Akira Maeda, Akihiko Kuniyasu, Daisuke Yamada, Takehiko Maeda, Akihiko Tsuji, Makoto Sawada, Hitoshi Nakayama. GLIA 64(11) 1938-1961 2016
  32. Therapeutic Strategy for Targeting Aggressive Malignant Gliomas by Disrupting Their Energy Balance. Ahmed M. Hegazy, Daisuke Yamada, Masahiko Kobayashi, Susumu Kohno, Masaya Ueno, Mohamed A. E. Ali, Kumiko Ohta, Yuko Tadokoro, Yasushi Ino, Tomoki Todo, Tomoyoshi Soga, Chiaki Takahashi, Atsushi Hirao. JOURNAL OF BIOLOGICAL CHEMISTRY 291(41) 21496-21509 2016
  33. Cancer pain relief achieved by disrupting tumor-driven semaphorin 3A signaling in mice. Takehiko Maeda, Daisuke Yamada, Kohichi Kawahara. NEUROSCIENCE LETTERS 632 147-151 2016
  34. mTORC1 is a critical mediator of oncogenic Semaphorin3A signaling. Daisuke Yamada, Kohichi Kawahara, Takehiko Maeda. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 476(4) 475-480 2016
  35. Tumor cell-derived secretory factor downregulates Semaphorin-3a in osteoblasts by activating mammalian target of rapamycin pathway. Daisuke Yamada, Kohichi Kawahara, Masanobu Ozaki, Takehiko Maeda. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 80(5) 942-944 2016
  36. Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells. Tanaka S, Nakada M, Yamada D, Nakano I, Todo T, Ino Y, Hoshii T, Tadokoro Y, Ohta K, Ali MA, Hayashi Y, Hamada J, Hirao A. Journal of neuro-oncology 121(2) 239-250 2015
  37. Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals. Daisuke Yamada, Takayuki Hoshii, Shingo Tanaka, Ahmed M Hegazy, Masahiko Kobayashi, Yuko Tadokoro, Kumiko Ohta, Masaya Ueno, Mohamed A E Ali, Atsushi Hirao. Journal of biochemistry 155(4) 227-33 2014
  38. Osteoclastogenesis is negatively regulated by D-serine produced by osteoblasts. Takeshi Takarada, Mika Takarada-Iemata, Yoshifumi Takahata, Daisuke Yamada, Tomomi Yamamoto, Yukari Nakamura, Eiichi Hinoi, Yukio Yoneda. JOURNAL OF CELLULAR PHYSIOLOGY 227(10) 3477-3487 2012
  39. NKX2.2 Suppresses Self-Renewal of Glioma-Initiating Cells. Teruyuki Muraguchi, Shingo Tanaka, Daisuke Yamada, Akira Tamase, Mitsutoshi Nakada, Hideo Nakamura, Takayuki Hoshii, Takako Ooshio, Yuko Tadokoro, Kazuhito Naka, Yasushi Ino, Tomoki Todo, Jun-ichi Kuratsu, Hideyuki Saya, Jun-ichiro Hamada, Atsushi Hirao. CANCER RESEARCH 71(3) 1135-1145 2011

Dr. Gotoh

  • 組織染色における固定法と染色溶媒の検討 後藤 仁志, 野地 亮太 Studia humana et naturalia p41-50 (2024)
  • A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice. Ako Agata, Satoshi Ohtsuka, Ryota Noji, Hitoshi Gotoh, Katsuhiko Ono, Tadashi Nomura Front Cell Dev Biol (2023)
  • Disruption of the anterior commissure in Olig2 deficient mice. Hitoshi Gotoh, Kohei Maruyama, Kengo Yoshii, Nao Yamauchi, Tadashi Nomura, Satoshi Ohtsuka, Ryuichi Shirasaki, Hirohide Takebayashi, Katsuhiko Ono Eur J Neurosci 57(1) 5-16 (2023)
  • Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains. Tadashi Nomura, Kohjiro Nagao, Ryo Shirai, Hitoshi Gotoh, Masato Umeda, Katsuhiko Ono Nature Communications 13(1) 96-96 (2022)  
  • STAT3 transcriptionally regulates the expression of genes related to glycogen metabolism in developing motor neurons. Hitoshi Gotoh, Tatenda Alois Chimhanda, Tadashi Nomura, Katsuhiko Ono FEBS letters 596(22) 2940-2951(2022)  
  • Cell Type-Specific Transcriptional Control of Gsk3β in the Developing Mammalian Neocortex. Tadashi Nomura, Hitoshi Gotoh, Hiroshi Kiyonari, Katsuhiko Ono Frontiers in Neuroscience 16 811689-811689 (2022)
  • Ultrastructural characteristics of oligodendrocyte precursor cells in the early postnatal mouse optic nerve observed by serial block-face scanning electron microscopy.　Katsuhiko Ono, Hitoshi Gotoh, Tadashi Nomura, Tsuyoshi Morita, Otto Baba, Mami Matsumoto, Sei Saitoh, Nobuhiko Ohno PloS one 17(12) e0278118 (2022)
  • Differential potentials of neural progenitors for the generation of neurons and non-neuronal cells in the developing amniote brain. Hashimoto Y, Gotoh H, Ono K, Nomura T Scientific reports 9(1) 4514-4514 (2019)
  • Opn5L1 is a retinal receptor that behaves as a reverse and self-regenerating photoreceptor Keita Sato, Takahiro Yamashita, Hideyo Ohuchi, Atsuko Takeuchi, Hitoshi Gotoh, Katsuhiko Ono, Misao Mizuno, Yasuhisa Mizutani, Sayuri Tomonari, Kazumi Sakai, Yasushi Imamoto, Akimori Wada, Yoshinori Shichida Nature Communications 9(1) 1255-1255 (2018)
  • Birthdate-dependent heterogeneity of oculomotor neurons is involved in transmedian migration in the developing mouse midbrain. Kawano K, Gotoh H, Nomura T, Ono K Journal of chemical neuroanatomy 94 32-38 (2018)
  • NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer.
  • Gotoh H, Wood WM, Patel KD, Factor DC, Boshans LL, Nomura T, Tesar PJ, Ono K, Nishiyama A Glia 66(12) 2684-2699 (2018)
  • Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain. Yamashita W, Takahashi M, Kikkawa T, Gotoh H, Osumi N, Ono K, Nomura T Development (Cambridge, England) 145(8) (2018)
  • Species-Specific Mechanisms of Neuron Subtype Specification Reveal Evolutionary Plasticity of Amniote Brain Development Tadashi Nomura, Wataru Yamashita, Hitoshi Gotoh, Katsuhiko Ono Cell Reports 22(12) 3142-3151 (2018)
  • The Future Vocation of Neural Stem Cells: Lineage Commitment in Brain Development and Evolution Tadashi Nomura, Hitoshi Gotoh, Katsuhiko Ono Neurochemical Research 43(1) 153-156 (2018)
  • Origin of Oligodendrocytes in the Vertebrate Optic Nerve: A Review Katsuhiko Ono, Yukie Hirahara, Hitoshi Gotoh, Tadashi Nomura, Hirohide Takebayashi, Hisao Yamada, Kazuhiro Ikenaka Neurochemical Research 43(1) 186-194 (2018)
  • Oligodendrocyte precursor cells in the mouse optic nerve originate in the preoptic area Katsuhiko Ono, Kengo Yoshii, Hiroyuki Tominaga, Hitoshi Gotoh, Tadashi Nomura, Hirohide Takebayashi, Kazuhiro Ikenaka BRAIN STRUCTURE & FUNCTION 222(5) 2441-2448 (2017)
  • Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities Masashi Zuiki, Tomohiro Chiyonobu, Michiko Yoshida, Hiroshi Maeda, Satoshi Yamashita, Satoshi Kidowaki, Tatsuji Hasegawa, Hitoshi Gotoh, Tadashi Nomura, Katsuhiko Ono, Hajime Hosoi Masafumi Morimoto NEUROSCIENCE LETTERS 653 296-301 (2017)
  • Glycogen serves as an energy source that maintains astrocyte cell proliferation in the neonatal telencephalon. Gotoh H, Nomura T, Ono K J Cereb Blood Flow Metab 37(6) 2294-2307 (2017)
  • Sulfatide species with various fatty acid chains in oligodendrocytes at different developmental stages determined by imaging mass spectrometry Yukie Hirahara, Taketoshi Wakabayashi, Tetsuji Mori, Taro Koike, Ikuko Yao, Masayuki Tsuda, Koichi Honke, Hitoshi Gotoh, Katsuhiko Ono, Hisao Yamada JOURNAL OF NEUROCHEMISTRY 140(3) 435-450 (2017)
  • Rapid and efficient gene delivery into the adult mouse brain via focal electroporation. Nomura T, Nishimura Y, Gotoh H, Ono K Scientific reports 6 29817-29817 (2016)