The musculoskeletal system (bones and skeletal muscles) serves not only to facilitate physical activity but also functions as a multitasking organ involved in the regulation of various other organs through minerals, metabolic products, and hormones.

A decline in bone mass or quality can lead to osteoporosis and fractures, which may subsequently result in increased risk of disability, bedridden states, and mortality. Moreover, osteoporosis is intricately linked with a myriad of conditions such as diabetes, arteriosclerosis, hypertension, dyslipidemia, chronic kidney disease, chronic obstructive pulmonary disease, depression, and dementia. Thus, it is imperative to consider bone health in the context of these associated diseases. Similarly, a reduction in skeletal muscle mass or function has been reported to correlate with cardiovascular diseases, cancer, dementia, and overall lifespan. Consequently, the musculoskeletal system is an important organ that underpins human vitality.

Our research laboratory aims to elucidate novel molecular mechanisms that maintain the quantity and quality of the musculoskeletal system, as well as to uncover the roles of newly identified hormones produced by this system. Through this understanding, we strive to develop preventive and therapeutic strategies for a variety of diseases grounded in the musculoskeletal system.